10/18/2023 0 Comments Bioptigen sd oct![]() However, data on normative values of the retina for wild-type C57BL/6– a common mouse model for the study of retinal diseases – is not available. Bioptigen SD-OCT technology is increasingly implemented in rodents for biometrical analysis as well as evaluation and management of retinal disorders. It contains the animal imaging mount with rodent alignment stage (a unique platform with adjusters that stereotactically secures mice within a cassette while mounted to a rotational stage) and a hand-held 840 nm SD-OCT probe (HHP) capable of axial resolutions of 5 micrometers (µm) –. Hand-held spectral domain ophthalmic imaging system (SDOIS) (Bioptigen, Inc., Durham, NC) represents an alternative non-invasive in vivo imaging device. Although SD-OCT provides non-invasive histological – grade sections of the rodent posterior segment, image acquisition is technologically cumbersome as human devices are retrofitted for animal use. With the advent of in vivo applications such as fundoscopy, confocal scanning laser ophthalmoscopy (cSLO), angiography, electroretinography (ERG), and optical coherence tomography (OCT), limitations associated with ex vivo histological preparations can now be circumvented. Inherent methodological limitations confound tissue integrity and curtail longitudinal evaluations within a single subject. Historically, e x vivo histological sectioning is used to study retinal disease in mouse models. Mouse models have been instrumental for understanding pathophysiology in a variety of retinal diseases –. The rapid, high resolution, non-invasive cross-sectional images produced by SD-OCT is an important tool for diagnosing and monitoring posterior segment pathology longitudinally. ![]() Spectral domain optical coherence tomography (SD-OCT) is an important imaging modality in clinical ophthalmology and vision science for characterizing morphology and understanding pathophysiological changes within the retina. ![]()
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